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Zai Lab has unveiled preclinical data indicating that its investigational bispecific antibody, ZL-1503, may offer rapid itch relief and reduce inflammation in atopic diseases. The findings, presented on April 18, 2026, highlight the potential of ZL-1503 to target both IL-13 and IL-31Rα pathways, which are associated with inflammatory and pruritic responses in conditions such as atopic dermatitis..
再鼎医药公布了临床前数据，表明其研究中的双特异性抗体ZL-1503可能在特应性疾病中提供快速止痒并减轻炎症。这些研究结果于2026年4月18日发布，强调了ZL-1503靶向IL-13和IL-31Rα通路的潜力，这些通路与特应性皮炎等疾病中的炎症和瘙痒反应相关。
The research demonstrated that ZL-1503 effectively inhibited signaling through these pathways in preclinical models. This dual mechanism of action reportedly led to a significant reduction in itch-related behaviors and markers of inflammation. These results suggest that ZL-1503 could address key symptoms of atopic diseases by simultaneously targeting two critical drivers of disease pathology.
研究表明，ZL-1503 在临床前模型中有效抑制了这些通路的信号传导。据报道，这种双重作用机制显著减少了与瘙痒相关的行为和炎症标志物。这些结果表明，ZL-1503 通过同时靶向疾病病理的两个关键驱动因素，可能缓解特应性疾病的主要症状。
Further studies will be needed to confirm these findings and evaluate the safety and efficacy of ZL-1503 in clinical settings..
还需要进一步的研究来证实这些发现，并评估ZL-1503在临床环境中的安全性和有效性。
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Date: April 18, 2026
日期：2026年4月18日
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